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现实世界中的外科医生吴妍珠（韩孝周 饰）听说了身为著名漫画家的父亲失踪的消息，于是赶到父亲的工作室寻找线索，偶然地进入了人气漫画《W》的世界。2016年的首尔，相同的空间、不同的次元，与漫画男主人公姜哲（李钟硕 饰 ）在现实与虚幻中交错展开的悬疑浪漫爱情故事。做个完全贴切的比喻就是，失去了严世藩的严嵩，就像拔掉了牙齿的老虎，空有一身肉。The newspaper said: "The total number of cancer deaths in the United States showed a downward trend for the first time in 2005." "Cancer is a chronic disease that can be treated, controlled and even cured." In the past, it was believed that cancer would lead to death, and it would take less than three months. Now it is believed that cancer is a chronic disease that can be treated, and the treatment method will change with the change of understanding. The decline in the death rate of cancer patients in turn proves that this change of understanding is close to the right direction. Western medicine came from the West. At present, the number of cancer survivors in the United States is 1/29 of the total population, while that in Shanghai is only 1%, which is far from other places. This shows that Shanghai's understanding and treatment of cancer are still shrouded by the shadow of past mistakes. Many innocent lives still die under the wrong medical understanding and medical methods.本剧描述了20世纪30年代初期，生活在上海的方家、韩家、郑家、阎家，因儿女的联姻，引出了一个又一个动人心弦、感人肺腑，令人荡气回肠的曲折故事。Telecommunications在妓寨丽春院长大的韦小宝不学无术，终日游手好闲，偷奸取巧，是个不折不扣的小无赖。一次，天地会总舵主陈近南刺杀清廷重臣鳌拜不遂，负伤逃入丽春院，得小宝相救。近南见小宝机灵过人，遂收其为徒。康熙派心腹太监海大富和御妹建宁公南下访寻高手，以歼灭奸臣鳌拜。海公公和建宁以为小宝武功盖世，决意征用他为朝廷效力。小宝入宫后，竟误打误撞建立连串功绩，极得康熙赏识，成为宫中大红人。建宁刁蛮任性，却对小宝情有独钟，但小宝不甘受她管束，反而乐于周旋于双儿、沐剑屏、方怡和阿珂众女之间。既为陈近南的得意弟子，又是皇上的头号宠臣，小宝左右逢源，感到忠义两难全。他厌倦了这种生活，最终放弃功名利禄，带着妻子们笑傲江湖。自己和刘邦筹划了许久的行刺，就更是无稽之谈了。