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本剧改编自ABC News/ABC Radio的同名播客，讲述Elizabeth Holmes及她的公司Theranos如何崛起及坠落。该剧根据史蒂夫-金的同名畅销书改编，著名制片人David E. Kelley担任剧集总监，Jack Bender参与制片并执导首集。 
　　故事描述一个疯狂的杀手用一系列可怕的信件和电子邮件来嘲弄一个退了休的警探，迫使这名警探私下展开调查行动。他发誓要将穷凶极恶的杀手绳之以法，以免他再次作案害人。Brendan Gleeson扮演主人公Bill Hodges侦探，在一个宿敌再次出现后被迫「结束」退休。Anton Yelchin扮演精神错乱的冰淇淋卡车司机Brady Hartsfield，同时是网络巡警的IT人员。事实上，他就是臭名昭著的「梅赛德斯杀手」。 
　　原著2014年6月出版，直接冲上《纽约时报》畅销书排行榜，并且赢得了爱伦坡最佳小说奖。史蒂芬-金计划撰写三部曲，《梅赛德斯先生》只是其中的第一本书。第二本书《捡到归我》（Finders Keepers）去年6月出版，第三本书《End of Watch》今年6月7日出版。在有人神秘地将他的注意力吸引到了证据之后，一位无所畏惧的所得税官员袭击了勒克瑙最有权势的人的宅邸。"Yes, Common carnivores, Whether it's a dog, Wolf, or the dog teeth of lion and tiger, They are all tapered sections, With a tip in the front, But this kind of thing is different, All of their teeth are the same, All of them are inverted triangles, And very thin, Both sides are like knives, It was all 'open-edged'. It was very sharp and very hard. When I pried its mouth with a dagger at that time, after priing it open, I could find many thin but obvious scratches on the blade of the dagger in the face of the sun. The dagger I used was made of steel. It was really surprising to me that the teeth could leave such marks on it. "Zhao Mingkai said.截杀？还是短暂的沉默之后，吕马童自言自语轻轻说道。嬴子夜站在原地，心情波动很大，她很清楚尹旭的来意和目的，无非就是想要自己去劝慰李斯。呼——吴明深呼吸一口气，努力排除心中紧张，让自己处于最佳状态。